BAR HARBOR, MAINE – The lack of animal studies and interventions to extend the healthy life cycle of human beings is limited by lack of animal models: traditional vertebrate models such as the mouse are too long to obtain fast results, and the most popular model, known as wheat C.elegans only three weeks, he is leaving from the evolutionary ladder.
In recent years, however, the turquoise scientist in Africa has developed scientists as a model to close this gap. Its short lifespan of four months to six months provides a quick indication of the effectiveness of anti-aging interventions, and its biological characteristics, including vertebrate genes and organs and a complex immune system, are directly relevant to the study. on human aging.
Thanks to a $ 75,000 grant from The Cotswold Foundation, the MDI Biological Laboratory will put the turquoise cloth in Africa (Nothobranchius furzeri(b) its increasing roster of animal models, reinforcing the institution's long-standing tradition of comparative research to understand the mechanisms of aging and regeneration.
"The turquoise pork of Africa is the shortest vertebrate surviving in captivity," said Aric Rogers, faculty member in the MDI Biological Laboratory, Ph.D. "Using it as a model we will be able to quickly identify and test the genes, gene trails and controllates that survive and survive, which could expand new therapies to lead a healthy life for the person." extension. t
The capacity of the new model means that it can be used as a platform to study how regeneration capacity reduces with age, allowing the institution to increase its new research focus on the interface between aging and regeneration. This focus was established in 2019 to add a course to the interrelationship between those areas to be repeated in 2020.
"We are grateful to The Cotswold Foundation for their support for our initiative to become the leader of the unpublished scientific territory at the interface of aging and regeneration," said Hermann Haller, M.D., president of MDI Biological Laboratory. "Because vertebrate, the turquoise pork of Africa opens doors that new insights into why aging occurs in humans."
Originally from East Africa, turquoise pork in Africa was first recognized as a new species in 1969. Although it was valued by enthusiasts of the aquarium for its magnificent thrust, it did not draw attention to scientists until 2003 on an aging animal model in the space between invertebrates and vertebrate models that last longer like the mouse and zebrafish.
An advantage of the new model is that it shares many signs of aging with people, including loss of muscle mass, reduced immune function, even memory loss. The initial research at the MDI Biological Laboratory, to be conducted by Rogers, Voot Yin, Ph.D, and Sam Beck, Ph.D., will focus on tracking the progress of these age-related changes.
Once scientists have identified aging biofuels in the new model, they will seek additional funding to use it to study the interface between aging and regeneration. Rogers hopes that he will be employed as a model by some faculty members, as well as visiting scientists and students enrolled in courses in these areas.
"The MDI Biological Laboratory is always dedicated to the idea of using the animal model best suited to the study of the biological problem at hand," explained Rogers. "With this exciting new model, we will be able to explore aging in an animal that goes back in a similar way to us, but at a much faster pace. Our own creativity is the only limit to discovery."
African turkeys are not new to the institution: in recent years it has been introduced during summer courses on aging and regeneration by visiting the Max Planck Institute Ph.D. Faculty of Dario Riccardo Valenzano, Ph.D. Aging Biology in Cologne, Germany, and Itamar Harel, Ph.D., Hebrew University of Jerusalem.
Valenzano and Harel were leaders in the development of colonial management techniques, laboratory protocols and genetic tools needed to establish the African pork as an animal model. Both are former post-doctoral doctors in Anne Brunet's laboratory, Ph.D., in Stanford University Medical School, one of the pioneers in the use of the new model.
African confusion cannot be imagined with another valuable model, killing the Atlantic (Fundus heteroclitus), or mummichog, residing in tidal estuaries such as Northeast Creek near the MDI Biological Laboratory. MDI Biological Laboratory scientists used the fatal Atlantic from Northeast Creek to study kidney disease, adapting to toxic contamination and more.
About the MDI Biological Laboratory
We aim to improve human health and health by uncovering the basic mechanisms of tissue repair, aging and regeneration, translating our findings for the benefit of society and developing the next generation of scientific leaders. For more information, visit mdibl.org.
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. (tagsToTranslate) Biology (t) Biochemistry (t) Cell Biology (t) Evolution (t) Genetics (t) Molecular Biology (t) Education (t) Grants / Funding (t) Mortality / Length (t) Aging