A way to defeat immortal cancer cells is found


Scientists of the Federal Polytechnic School of Lausanne in Switzerland found two enzymes that protect chromosomes from damage by active forms of oxygen and shortening of telomeres. Blocking their activity will help in the fight against cancerous tumors in which high activity of telomerase is observed. This is reported in a press release on MedicalXpress . Before dividing the cell, its DNA is folded into chromosomes, which protects the genetic material from damage. The ends of chromosomes, in humans consisting of repeats of TTAGGG, are called telomeres. They prevent the loss of genes during mitosis, because DNA polymerase is not able to synthesize a copy of DNA from the very end, but every time the replication occurs, the telomere shortens. The telomerase enzyme restores telomeres, but its excess activity contributes to cancer, in which malignant cells become almost immortal It is shown that the enzymes PRDX1 and MTH1, which have an antioxidant effect, prevent damage to telomeres by active forms of oxygen. Scientists blocked the activity of compounds in cancer cells and found that with each division cycle, telomeres began to contract until they completely disappeared. It turned out that suppression of enzyme functions disrupted the activity of telomerase. More important news in the Telegram channel «The ribbon of the day» . Subscribe!


Please enter your comment!
Please enter your name here

This site uses Akismet to reduce spam. Learn how your comment data is processed.