North West Ambulance Service said two victims died on the scene after the crash at 12.04 on the A34, Melrose Way, Alderley Edge.
Another man was taken to the Manchester Royal Infirmary and another child was taken to Manchester Children's Hospital.
Your conditions are not known at this time.
Seven more were brought to the Macclesfield District General Hospital with minor injuries.
The emergency services said the crash was a "serious incident".
Cheshire police investigate the crash and call for witnesses.
In a statement, Cheshire police said, "Police investigating a heavy collision in Alderley Edge are calling for witnesses.
"At 4:04 pm on November 4, emergency services were called to make a serious collision on the A34 Melrose Way in Alderley Edge.
"The collision was a car and a minibus, and a number of victims were treated at the scene and taken to a hospital.
"The road was blocked between the Alderley Park roundabout and the Alderley Edge roundabout while the ambulance service was working locally."
Firefighters were also called into the scene.
The Cheshire Fire and Rescue Service said in a statement, "The firefighters were called to a heavy collision on the Melrose Way, A34, Alderley Edge. The collision involved a minibus and a car. The crews supported the emergency service on site and challenged the victims. "
Anyone who witnessed the crash was asked to call the Cheshire Police at number 101 to provide incident number IML 231304.