The work in progress on brown fat must therefore be reviewed thanks to the findings made at the CHUS Research Center. Should this be seen as bad news, as a setback for science?
“In my eyes, no, it’s even the opposite. The result of our research proves the importance of researching, examining and reexamining what we do. In research, we are wrong half the time when we start a hypothesis, hence the importance of research ”, he insists.
“Normally, people who develop drugs do it in animal models and then do clinical trials in humans. What we did is different, it’s not what is normally done: we went to check the mechanism behind that. It proves that we cannot predict everything from the animal model, and this is an aspect of research that is important to me, ”insists Dr. Carpentier.
A second phase of the research, which will begin in the fall, will attempt to validate the effect that this new way of activating brown fat with pharmacological help can have on the energy expenditure of the human body. This will be followed by clinical trials, which will last a few years, to assess the longer-term benefits for diabetes.
Stimulating this fat is of great benefit in order to eliminate sugar and excess fat in some people.
Remember that in Canada, 8% of the population suffers from this disease.
The research is carried out under the supervision of Drs André Carpentier and Denis Blondin, professor-researchers at the Research Center of the Center hospitalier universitaire de Sherbrooke of the CIUSSS de l’Estrie-CHUS and at the Faculty of Medicine and Health Sciences of the ‘Université de Sherbrooke, and Dr. Camilla Schéele from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen (Denmark).
Several other researchers collaborated on the study, including some from the University of Leiden (Netherlands), the Center for Physical Activity Research at Rigshospitale (Denmark), the University of Ottawa, Laval University and from the University of Sherbrooke.