Unsurprisingly, age was the most important factor. From the age of 50, the statistical risk of severe courses increased by a factor of 1.5 every five years of life. People over the age of 80 had an almost 17-fold increased risk compared to those aged 45 to 50. In addition, it was just as unsurprising that previous illnesses, organ damage, cancer or the use of immunodepressant drugs usually doubled the risk of severe courses.
The virus evolution, on the other hand, proved to be an advantage for most of the sick: Omicron had the clearly larger share of breakthrough infections overall at 70.8 percent (Delta came to 26.6 percent). But with the then severe infections, it was exactly the opposite. At Delta, 16.6 percent of vaccine breakthroughs were serious and 2.5 percent fatal, at Omicron only 6.7 percent were serious and 0.9 percent fatal.