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An artificial intelligence algorithm can determine in a non-invasive way, with an accuracy of around https://www.consalud.es/70%, if a in vitro fertilized embryo have a normal or abnormal number of chromosomes, according to a new study led by a team of researchers from Weill Cornell Medicine.
Having an abnormal number of chromosomes, a condition called aneuploidy, is one of the main reasons why embryos derived from in vitro fertilization (IVF) do not implant or result in a healthy pregnancy. One of the current methods for detecting aneuploidy involves biopsy-like analysis is genetic testing of cells from an embryo, an approach that add costs to the IVF process and it is invasive for the organism. [banner-DFP_1]
“Our hope is that ultimately we can predict aneuploidy in a completely non-invasive way, using artificial intelligence and computer vision techniques.”
The new algorithm, STORK-Adescribed in an article published on December 19, 2022 in Lancet Digital Health, it can help predict aneuploidy without the disadvantages of biopsy. It works by analyzing microscopic images of the embryo and incorporates information about maternal age and the IVF clinic score on the appearance of the embryo.
“Our hope is that ultimately we can predict aneuploidy in a completely non-invasive way, using artificial intelligence and computer vision techniques,” said study lead author Dr. Iman HajirasoulihaAssociate Professor of Computational Genomics and Physiology and Biophysics at Weill Cornell Medicine, as well as a Fellow of the Englander Institute of Precision Medicine.
According to Centers for Disease Control and Prevention of the United States, more than 300,000 IVF cycles in the country in 2020which led to some 80,000 births. IVF experts are always looking for ways to increase this success rate, to achieve more successful pregnancies with fewer embryo transfers, which means developing best methods to identify viable embryos.[banner-DFP_4]
Fertility clinic staff currently use microscopy to evaluate embryos for large-scale abnormalities that correlate with poor viability. To obtain information about chromosomes, clinicians may also use a biopsy method called preimplantation genetic testing for aneuploidy (PGT-A), mainly in women older than 37 years.
To develop a computational approach to embryo evaluation that took advantage of the pioneering use of time lapse photography of the Embryology Laboratory, for which the researchers from the Center for Reproductive Medicine teamed up with their colleagues from the Englander Institute.
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