Scottish captain Stuart McInally called on his page on "Do it For Doddie" by raising the trophy for rugby legend against Wales in Cardiff today.
Weir, who is battling motor neurone disease (MND), will be standing on the grandstands of the principality on Saturday for the game – and Gregor Townsend's team is determined to show the 48-year-old former second series.
"It's first and foremost another test match, but playing for the Doddie Weir Cup is as special as it gets for the Scottish team," said McInally.
Doddie Weir (third left) with his sons and former Scottish stars Gary Armstrong and Al Kellock
"It would be huge for us to take the trophy because he's such an inspiring guy." It's something we've talked about, and we want to make sure that we make it proud and proud of the country.
"Every time we wear the jersey, we do our best. This is of course. But having something else in his honor makes it even more special.
"The fact that Doddie is there for the game and the fact that he was in our team race just makes the excitement even bigger. We are inspired by him and want to show a performance that everyone, especially him, is proud of. He will definitely be in the front line. "
Over 60,000 spectators are expected at the match in Cardiff, where Weir will be guest of honor in a game aimed at raising awareness of his charity funding research into MND. A substantial sum was also raised after the Welsh and Scottish Rugby unions made an eleven-hour turnaround and agreed to make a six-figure donation after a public setback occurred when it became known that no percentage of the revenue was provided from the gate for charity.
"I think the media and publicity surrounding the Doddie Weir Cup is great – to do exactly what was meant to raise awareness of its charity, which is funding the research on motor neurone disease," McInally continued.
"It's another chance for us all to play for Scotland and try to win for Scotland.
"Yes, as I said, it's a chance to move the Thistle, but it's awesome that we can also bring Doddie's foundation to the attention. It is also a very serious challenge to come and win here. "
An emotional McInally said that all of Scotland is rooted in Weir's fight against MND, which has touched many people's hearts.
McInally said that all of Scotland was rooted in Weir in its fight against MND
The teams fight for the trophy in Cardiff on Saturday, which was named in honor of the rugby legend
"It's hard to put into words what Doddie means to everyone," he said. "He's going through a difficult time, but his only focus is to raise awareness and raise money so that other people do not have to go through what he's going through. Everyone in Scotland knows him and what he does.
I'm thinking of the New Zealand game that we played in Murrayfield last November. It was amazing how he and his sons went to the pitch and presented the match ball.
"I do not think the house was a dry eye, even among the players, we were really proud that we could make it part of the day, and it's great to see that his heritage is still growing and so is he Part of this game is.
"He will now have a trophy forever named after him, which we can not really put into words for all of us, but it's something we talk about a lot as a Scotland squad."
Scotland's Deputy Head Coach Matt Taylor, a former Weirs team-mate at Border Reivers, said the entire coaching staff and backroom staff shared McInally's desire to perform well for Doddie.
"Having him here and playing a cup in his honor is a big motivation for us," said Taylor. "He was in and around the team and we talked about what an inspiration he is for everyone.
"We see what he's going through, and it means a lot to the guys wearing the blue jersey, and I'm sure we'll come down here to win the trophy.
"I was fortunate enough to have played with Doddie down in the limits, so I know him very well, he was a good player and also a bit of a joker in his time, he could be serious if he had to, but he could Enjoy yourself too, we were lucky enough to have him in the Borders team. "