Exercise program slows deterioration of kidney function in…


San Francisco – A structured and partially supervised exercise intervention can slow the deterioration of mobility-impaired seniors who spend a lot of time sitting.

This is shown by the JAMA Internal Medicine published results of a new analysis of the randomized controlled LIFE study (2022: DOI: 10.1001/jamainternmed.2022.1449).

Observational studies have already yielded initial indications that more physical activity is associated with a slower decline in kidney function.

“Our analysis shows for the first time in a large clinical study that physical activity and exercise can improve kidney function in older people,” write Michael Shlipak of the Department of Medicine at the University of California at San Francisco and his colleagues.

1,199 participants in the Lifestyle Interventions and Independence For Elders (LIFE) study were included in the analysis. From 2010 to 2013, she studied the impact of a structured, partially supervised, moderate-intensity exercise program over 2 years on the health of elderly people with mobility impairments. A consultation on healthy aging with workshops, brochures and training instructions served as a control.

Step by step to better kidney function

In the intervention group, both the number of steps achieved and the total daily duration of physical activity were measured in study participants aged 70-89 who had previously led a predominantly sedentary lifestyle.

The primary endpoint of the current analysis was change in cystatin C-based calculated eGFR (eGFRCysC). In addition, the researchers determined the proportion of participants with rapid eGFRCysC decline (>6.7% per year).

Prescribe sporting activities in a targeted manner

At baseline, the two groups were comparable in terms of age, comorbidities, and eGFRCysC. The exercise intervention was associated with a significantly smaller decrease in eGFRCysC over 2 years than the health counseling.

The mean difference was 0.96 mL/min/1.73 m2 (95% CI 0.02-1.91). The intervention arm of the study was also 21% less likely to experience rapid eGFRCysC decline than the control arm (OR 0.79 [95-%-KI 0,65-0,97]).

“Physicians should consider prescribing targeted physical activity and moderate-intensity exercise to their elderly patients to counteract the decline in eGFR,” the US researchers conclude. © nec/