The results of a study conducted by a team of scientists from the University of Tulane and the School of Medicine of Harvard University (USA), published in the journal European Heart Journal.
The researchers analyzed data on nearly 36 and a half thousand American women from 2004 to 2012. At the start of the study, in 2004, the age of these women was 60 years or more, while none of them had cardiovascular diseases at that time. Participants were asked to remember whether they took antibiotics when they were young (from 20 to 39 years), at a mature age (40–59 years), and now, at an older age, and if so, what was the duration of the courses.
According to the survey, the participants were divided into four groups: first included those women who never took antibiotics, the second – those who had never taken such drugs for more than 15 days, and the third – those who happened to take them from 15 days to two months, and in the fourth – those who took antibiotics for more than two months in a row. Over the next years, the study participants reported every two years whether they took antibiotics, and if so, how long. During this time, 1056 women were diagnosed with various cardiovascular diseases.
When researchers took into account such factors as nutrition, lifestyle, obesity or obesity, the reasons for taking antibiotics, and so on, it turned out that long-term medication in mature and elderly people increases the chances of developing heart and vascular diseases.
Thus, in elderly women who took antibiotics for two months or more, the risk of cardiovascular diseases was increased by 32% compared with their peers, these drugs were not taken. In adulthood, long-term antibiotic use increases this risk by 28%. In young women, this relationship was not found.
This phenomenon can be explained by the fact that antibiotics during a long course of administration seriously disrupt the balance of microorganisms living in the intestines. This can ultimately lead to such consequences as inflammation and constriction of blood vessels, leading to the development of cardiovascular diseases, suggested study author Professor Lu Qi.