Kylian Mbappe scored twice to reach her season to 20 when the French World Cup winner went to Paris, a former Monaco club 4-1 race on Wednesday.
The victory kept eight clear points on top.
They registered their 50th goal of the league campaign from 20 games.
Monaco came away from PSG with a point in an attractive 3-3 tree in the capital last weekend but they only had a similar threat three days later.
Mbappe was on target in the 24 minutes and the 90th minute with Neymar getting penalties in the first half of the stop time.
Pablo Sarabia sent another person in the 73th minute, just seconds after his emergence as a representative.
Ibrahima Bakayoko found late consolation for Monaco, hitting Kaylor Navas' magnificent goal.
"In each area, we were better than Sunday," said Thomas Tuchel, PSG coach.
"It is a deserved victory, we had enough possession."
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Ángel Di María
Ousmane Dembélé and Kylian Mbappé
Zlatan Ibrahimović and Robinho
David Beckham and Darius Vassell
Tuchel added his attacking stars 'Fab Four'; held in Mbappe, Neymar, Mauro Icardi and Angel Di Maria.
His decision was to pay dividends when Di Maria changed over a cross for Mbappe to score the openings.
Monaco's goalkeeper, Benjamin Lecomte, denied Mbappe on two other occasions in the first half.
Neymar made 2-0 from the penalty spot in injury time after Kamil Glik was afraid of Layvin Kurzawa.
Sarabia's co-representative established Sarabia's goal before Mbappe completed the club race which he entered in 2015.
"We can make our plan with our four attackers," said Tuchel.
"For Icardi, it's not a negative game. It's a good mix."
"Kylian and Neymar carry the ball a lot, Mauro is able to work with us, for the team, to open spaces.
"He didn't score in two games, but he works. There is no doubt about it.
He said: "The objective of the game was to win, take the three points to improve our site.
"We have the best players but I want to have the best team in every game."
For Monaco coach, Robert Moreno, the defeat in his sobering experience was coming after an exciting Sunday draw in the French capital.
"I am extremely pleased and proud of my team," Moreno said after the first game he was led to be hit by Monaco at the end of Stade Louis II.
"It is a different outcome to Sunday but tonight we have achieved three goals for the counter-attack and punishment.
"At 3-1, we took risks but if we managed to achieve the second, the mental state would change and the last few minutes would be interesting."
Rennes is third in the table, five points behind Marseille and 13 from PSG after a 1-0 win over Nimes.
Adrien Hunou scored the winner in the 64th minute to ensure he won the seventh game in the last seven games.
Nimes are the second bottom, three points behind Amiens who pulled 1-1 at home to Reims.