Monday, June 17, 2019
Home Health Medications contain not so harmless excipients

Medications contain not so harmless excipients

Nine out of ten drugs contain excipients that can cause allergies or intestinal disorders, according to a study. Lactose, peanut, dyes: Are these substances really dangerous and can they be easily replaced?

" The majority of medications contain inactive ingredients that can cause adverse reactions and affect the safety and tolerability of these medications ". Here is the unmistaken finding of MIT researchers and the Harvard Medical SchooBoston in their study published March 13 in the journal Science Translational Medicine.

Up to 35 excipients in one tablet

Researchers analyzed 42,052 drugs from the American Library of Medicine (NLM) and discovered that 92.8% of drugs contain at least one inactive substance that could lead to an allergic reaction. In total, excipients account for 71% of the weight of a tablet, compared to just 29% for Active Pharmaceutical
There are some active ingredients in some … "data-image =" " data-url = "/ health / definitions / medicine-active-principle-15081 /" data-more = "Read more">active substance herself. On average, a drug contains more than eight different excipients, but the authors have counted up to 35 different formulations.

Do allergic people have to give up treatment?

For example, 45% of drugs contain Lactose Structure
Lactose is a diholoside, that is to say a complex sugar composed of the combination of two simple sugars, glucose and galactose, connected by a particular bond of osidic acid (hence the name … "data -image = "" data-url = "/ health / definitions / biology-lactose-8703 / "data-more =" Read more ">lactose, a carbohydrate, simple sugars, complex sugars, … "data-image =" -roux.jpg "data-url =" / health / definitions / nutrition-sugar-16105 / "data-more =" Read more ">sugar likely to cause Causes of … "data-image =" "data-url =" / health / definitions / medecine-allergy-2956 / "data-more =" Read more ">allergies in sensitive people; 55% contain an oligosaccharide sugar. They are also distinguished according to the number of carbon atoms in their chemical structure, such as trioses, pentoses and hexoses. The … "data-image =" 3.jpg "data-url =" / health / definitions / biology-monosaccharide-786 / "data-more =" Read more ">monosaccharide or polyol, which can cause intestinal disorders. Some dyes, such as tartrazine, are thought to aggravate asthma attacks.

" If these substances are, in general, too small to cause an effect, very sensitive patients may be affected , Says Daniel Reker, a co-author, at the site reverse. " The problem for these patients is that they have to make a choice between their allergy and the illness they are being treated for ". And there is not always an alternative: 100% of the treatments for the biosynthesis of progesterone
Progesterone is a sex hormone, similar to estrogen, synthesized by the corpus luteum of the ovaries or in the placenta, from pregnenolone, … "data-image =" https: //fr.cdn.v5.futura- "data-more =" / health / definitions / medecine-progesterone-2820 / "data-more =" Read More " >progesterone thus contain peanut, notes the researcher.

A study "false alarmist"

For François Chast, Honorary President of the National Academy of Pharmacy, this kind of alarmist studies simply does not make sense. " It takes 10 to 15 grams of lactose to trigger a lactose allergy. However, a medicine will contain a maximum of 300 mg "Says the specialist. Tartrazine? " It is much more dangerous for an asthmatic to walk in the forest where there are lots of pollen than to absorb a pill containing a few milligrams of tartrazine "Laughs the practitioner. The latter, however, agrees on one point with the authors of the study: the need to clean up the drug formulations. " It is quite possible to reduce preservatives or dyes in many specialties », Assures François Chast.

Excipients: useful or not?

Most of the time, these substances are used for marketing purposes to give a nice sometimes color … "data-image =" midioriginal / 7/9/5 / 7951943cc1_85596_couleur.jpg "data-url =" / sciences / definitions / physics-color-4126 / "data-more =" Read more ">color or a glossy tablet coating. But it's not always easy: in 2017, the Merck laboratory thought it would do well to replace lactose with Levothyrox by mannitol, an excipient with no known effect. The result: an outcry of patients complaining of side effects with the new formula. In Europe, regulations require manufacturers to indicate excipients with known effect on the packaging and in the package leaflet. They are 47 in France, including the structure of aspartame
Aspartame is the binding of two natural amino acids, aspartic acid and phenylalanine. Phenylalanine is esterified with methyl, giving aspartame the other name of … "data-image =" /a/1/3a19b886ed_50036588_aspartame.jpg "data-url =" / health / definitions / biology-aspartame-9166 / "data-more =" Read more ">aspartame, the Structure of glucose
Of chemical formula C6H12O6, glucose is in cyclic form (pyranose). It has isomers, that is to say molecules that have the same chemical formula (this is the case … "data-image =" /buildsv6/images/midioriginal/6/8/b/68bd6b2dfc_50034235_glucose-dp.jpg "data-url =" / health / definitions / biology-glucose-736 / "data-more =" Read more ">glucose, thestarch of Wheat History, this plant of the genus Triticum
Historically, in the Middle Ages and the Renaissance, the word bleds referred to annual crops. In the eighteenth century, the term "wheat" … "data-image =" jpg "data-url =" / planet / definitions / botanical-ble-16233 / "data-more =" Read more ">corn or sesame oil.

These excipients are mentioned for information purposes because no test ofallergology is performed by the National Agency for Drug Safety (ANSM) which publishes this list. One or two cases of adverse effect are sufficient to mention an excipient. Also included in the package leaflet are all other excipients with no known effect, such as stearate
Symbol: MgNuclear number: 12Electrons by energy level: 2, 8, 2Mass atomic … "data-image =" /8/3/3830398672_117968_magnesium.jpg "data-url =" / sciences / definitions / chemistry-magnesium-775 / "data-more =" Read more ">magnesium or gelatin.

What you must remember

  • Of 10 drugs, 9 contain excipients that can cause allergies or intestinal disorders.
    These non-active substances represent 71% of the weight of a drug.
    The quantities contained in a tablet are, however, very insufficient to constitute a real problem.

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It will interest you too

Counterfeit: beware of drugs sold on the Internet Counterfeiting affects all sectors, even drugs. Copies imitate the name and form of existing treatments but do not contain active ingredients. Worse, some may even be dangerous. The Anti-Counterfeit Drug Research Institute (IRACM) talks about it during this video.



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