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Molecule offers benefits of physical exercise

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One molecule has been shown to offer benefits from physical exercise, without the need for physical exercise. Still, a miracle pill is far from a reality.

Physical exercise alters more than 9,800 molecules in our blood, in a process that scientists call Cellular “symphony”. Despite the thousands of molecules involved, not all have the same benefits for the human body.

A team of researchers based at the Stanford University School of Medicine in the United States has identified a specific molecule that appears to play a huge role.

The study authors looked at what happens to molecules in the blood plasma of rats after they run on a treadmill to exhaustion.

According to the portal Freethinkthe compound C12H14NO4 increased significantly, with researchers later finding it to be N-lactoil-phenylalanine, or “Lac-Phe”.

The modified amino acid is synthesized from lactic acid — which is produced in abundance during intense physical exercise — and phenylalanine, one of the building blocks of protein.

After experimenting with laboratory mice, the researchers tested the same in race horses is at humans. The results were similar, leading the scientists to conclude that Lac-Phe is the “most significantly induced circulating metabolite”.

To see if this molecule is responsible for transmitting some of the “miraculous” health effects of physical exercise, the researchers donned their lab coats and returned to the lab.

To this end, they injected Lac-Phe into obese mice, discovering that significantly reduced appetite and body fate improved glucose tolerance during the ten-day study period.

Interestingly, Lac-Phe did not impart these benefits to healthy, lean mice. It also did not work when given orally, indicating that Lac-Phe may not work as a “magic pill” of physical exercise.

Lac-Phe further regulated the beneficial effects of physical exercise in a test in which scientists genetically modified mice lacking a key enzyme to produce Lac-Phe. these mice lost much less weight than mice in the control group.

Potentially, this molecule could reduce the severity of the osteoporosis, heart disease, diabetes, cognitive decline and other health problems that exercise is known to help treat.

“Future work discovering the molecular and cellular mediators downstream of Lac-Phe action on brain may provide new therapeutic opportunities to capture the cardiometabolic benefits of physical activity for human health. Nature.

Daniel Costa, ZAP //

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