The decision was made as Tropical Storm Ian is expected to become a hurricane by Monday and hit Florida’s Gulf Coast.
The rocket launch was originally scheduled for Tuesday.
This is the third postponement of the launch of the Artemis 1 mission, after fuel leaks and other technical issues caused the first two postponements.
NASA may attempt to launch its lunar rocket on October 2.
However, if NASA removes the rocket from the launch pad – a decision the US agency will make on Sunday or early Monday – it would likely mean a long wait before attempting a lunar rocket launch, which could only come in november.
This mission should mark the very first flight of the American program to return to the Moon, dubbed Artemis.
Artemis 1, which will be done without astronauts on board, aims to test the rocket and the capsule to ensure that they can transport a crew safely to the Moon, from 2024.
In 2024, the Artemis 2 mission will carry astronauts to orbit around the Moon, without landing there.
For its part, the crew of Artemis 3, a mission scheduled for 2025 at the earliest, should land on the Moon.
The last time humans landed on the moon was on Apollo 17 in 1972.
The Artemis program plans to send the first woman and the first person of color to the Moon.
This NASA-led program relies on international collaboration, including with the European Space Agency, the Canadian Space Agency, the Japan Aerospace Exploration Agency and several commercial partners.