Parkinson's disease would start in the appendix

Parkinson's disease would start in the appendix

Parkinson's disease has long been considered a brain disease but several studies have pointed to the role of the digestive system.The authors of a study based on medical data of 1.7 million Swedes, followed for some during a half century, found that those who had had a Following the temperature rise, the material usually undergoes internal transformations (pyrolysis) by injecting … "data-url =" / sciences / definitions / physics-ablation -2067 / "data-more =" Read more "> removal of the appendix at the beginning of their life had a risk of developing Parkinson's disease reduced by 19% The effect seems specific to Swedes living in rural areas. For them, the risk is reduced by 25%, while in urban areas, a reduction in risk could not be observed. As for those who developed Parkinson's disease, the researchers found that an appendectomy (removal of the appendix) was the After a three-and-a-half-year delay, the lead author, Viviane Labrie, of the Van Andel Research Institute, Michigan, told a conference call with the press on Tuesday. "Our work suggests that the appendix may play a role in the onset of Parkinson's disease," she explained, noting that this role may not have been exclusive.Links between Parkinson's disease and digestive system Parkinson's patients also suffer from gastrointestinal problems, such as constipation, appeared a decade or more before the Examples of symptoms
The symptoms can affect different organs:

muscle pain, joint pain, headaches, digestive problems, disorders of the … "data-image =" https://en.cdn.v5.futura-sciences.com/buildsv6/images/midioriginal/e/8/ 8 / e882bacd5b_96032_symptome-woman-mal-head.jpg "data-more =" / health / definitions / medecine-symptom-834 / "data-more =" Read more "> symptoms such as tremors and other motor problems. has prompted the scientific community to take an interest in the role of the digestive tract. The appendix is ​​a storage site for intestinal bacteria and also seems to play a role in the innate or nonspecific response.
The answer no … "data-image =" https://www.cdn.v5.futura-sciences.com/buildsv6/images/midioriginal/e/3/4/e349838f03_50084101_globule-blanc.jpg "data-url = "/ sante / definitions / medecine-immune-system-2722 /" data-more = "Read more"> immune response.It is also the "reservoir" of a protein Roles
Proteins can perform a variety of functions within the cell or organism.
They can have:
a structural role (like the actin or the tubulin which … "data-image =" https://fr.cdn.v5.futura-sciences.com/buildsv6/images/midioriginal/4/6/e/46e94f9da7_50034188_actine -thomas-splettstoesser-cc.jpg "data-url =" / health / definitions / biology-protein-237 / "data-more =" Read more "> key protein in Parkinson's disease, named alpha-synuclein, including in abnormal form.Or, this protein is abundant in the appendix in everyone, sick or not, which suggests to researchers that the abnormal protein sometimes manages to escape from the appendix to the brain function
Located in the cranial box, the brain is the seat of higher functions (cognitive functions, senses, nervous responses) and vegetative functions. It is therefore an essential organ that ensures the regulation of all … "data-image =" https://www.cdn.v5.futura-sciences.com/buildsv6/images/midioriginal/5/c/b /5cb474dd85_121782_cerveau-3d.jpg "data-url =" / health / definitions / biology-brain-3125 / "data-more =" Read more "> brain, where it would cause damage." This protein does not like to stay in the same place, explains Viviane Labrie, she is able to move from Neural Structure
Each neuron is composed of:
of a cell body or pericaryon with the nucleus, very many ramifications of the dendritic type (hence … "data-image =" https://fr.cdn.v5.futura-sciences.com/buildsv6/images /midioriginal/4/8/4/4845b46c32_50034180_neurone-dr.jpg "data-url =" / health / definitions / biology-neuron-209 / "data-more =" Read more "> neuron in neuron." And precisely, a nerve, the role of the vagus nerve
On the motor level, … "data-image =" https://www.cdn.v5.futura-sciences.com/buildsv6/images/midioriginal/a/9/1/a91b7607d7_50037872_nerf-vague.jpg "data- url = "/ health / definitions / medical-nerve-wave-11240 /" data-more = "Read more"> vagus nerve, connects the digestive tract to the brain Experiments have shown that the protein was able to borrow this way. "If it enters the brain, it can set up and develop until it has neurotoxic effects that could lead to Parkinson's disease," adds the researcher.Is it necessary to withdraw her appendix? The study's authors warned the press that it was not a matter of recommending everyone to remove the appendix. "We also do not say that if you had an ablation, you will not have Parkinson's disease, Viviane Labrie warns, but this work provides a further clue to the role of the small organ, which may one day lead to to neutralize this reservoir. For the moment, a cause-and-effect relationship has not been established. As is the case with studies of this type, many factors not taken into account could explain the difference between those who have undergone ablation and others.In addition, as recalled by the statistician, Kevin McConway, of The Open University studies have been conducted in the past on the link between appendicectomy and various diseases, sometimes leading to increased risk, sometimes to reduced risk. A study of Danes, published in 1996, included an increased risk of Parkinson's disease, not reduced. But in conclusion, the appendix appears more and more as a serious candidate for the resolution of the mystery of Parkinson's disease. A mystery with which 10 million people live today in the world.Par Parkinson's disease: gut and recycling of mitochondria involved Interested in what you just read? Subscribe to the newsletter The daily : our latest news of the day. This will interest you too! Did you like this article? Feel free to share it with your friends and help us spread Futura :)! The Editor thanks you. .

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