The final price, which includes taxes and commissions, is 17 times the upper limit of Sotheby's original estimate of $ 32,000.
This bottle with the stained label is one of 600 copies produced in 1945, just before the Romanée-Conti estate tears the vines for replanting then.
Romanée-Conti is often considered the greatest Burgundy wine, perhaps the most prestigious vintage in the world.
The estate is located on a plot of less than two hectares and now produces only between 5,000 and 6,000 bottles per year.
It is part of the Côte de Nuits, a strip of hillsides located north of the Côte d'Or.
The record for a bottle of standard wine was so far $ 233,000 for a Chateau Lafite Rothschild of 1869, auctioned at a sale in Hong Kong in 2010.
Three copies of the same vintage had been sold that day at the same price.
All sizes combined, the old record was 2007 for a jeroboam (3 liters) Mouton-Rothschild vintage 1945, sold in New York for 310 700 dollars.
A few minutes later, at the same auction on Saturday, another 1945 vintage Romanée-Conti bottle was auctioned for $ 496,000, establishing the second-highest price ever seen at auction for wine.
The lots sold Saturday came from the personal collection of Robert Drouhin, who directed from 1957 to 2003 the house Joseph Drouhin, one of the largest in Burgundy.
The Domaine Joseph Drouhin has 73 hectares, most of which are Grand Cru and Premier Cru. Maison Joseph Drouhin was the exclusive distributor of the Romanée-Conti estate for France and Belgium from 1928 to 1964.
Three other bottles of Romanée-Conti, magnums (1.5 liters or double a standard bottle) vintage 1937, each reached $ 310,000 Saturday.
Earlier, two 1945 vintage batches of La Tâche, which belongs to the Romanée-Conti estate but has a significantly larger average size and average production, had been sold for $ 297,600 and $ 248,000 respectively.
Each lot, however, included three bottles.
In total, the sale yielded $ 7.32 million per hundred lots, or more than $ 73,000 on average per lot.