Perrine Royal, Guillaume Sandoz, Brigitte Wdziekonski and Pablo Avalos Prado work on the hereditary causes of migraine. – A. Macarri / univ-cotedazur.

  • If the hereditary causes of headaches were known, this was not the case with their mechanism.
  • According to this Valrose team, a genetic mutation causes the dysfunction of a protein.
  • The Niçois then highlighted two new targets in the treatment of migraine.

The small team at Valrose's laboratory conducts basic research. From experience to experience, these four researchers have been led to work on migraine. If the hereditary causes of headaches were known, this was not the case with their mechanism. This is what the people of Nice have demonstrated, paving the way for new treatments on which they are also working.

According to this team, a genetic mutation causes the dysfunction of a protein. "This highlighted mechanism had never been described, says the laboratory manager who coordinated the research with the CNRS and the
Inserm, Guillaume Sandoz. This mechanism makes it possible to produce an unexpected second protein that inhibits channels in certain neurons. This leads to an increase in the electrical activity of these neurons. And so triggers the migraine. "

Soon drugs

Demonstrating a new hereditary disease mechanism, the Valrose team then highlighted two new targets in the treatment of migraine. "We have experimented in mice and rats: if we specifically suppress the expression of this channel, we generate the migraine. So if we activate, we have the opposite effect, he points. Now that we have new targets, we will test in the coming months on the rodent drugs that activate these channels. "

A hope in the medical treatment of headaches, 15% of adults being affected by this disease. "It's hard to know when treatments will be available," warns researchers. We test drugs, we work with industry. Always from their laboratory Nice.

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