Scientists have uncovered an unusual relationship between obesity and body temperature

Scientists have uncovered an unusual relationship between obesity and
 body temperature

12:43 03/13/2018 (updated: 14:30 13/03/2018 ) 9916 18 6th MOSCOW, March 13 (Itar-Tass) – RIA Novosti . Disturbances in the work of genes that control body temperature and its reaction to cold can be one of the main causes of obesity, scientists who published the article in Journal of Neuroscience .
Scientists found 5 more genes responsible for migraine attacks “Despite the fact that the body temperature in mice and humans is different, the genes and receptors responsible for the recognition of cold and reaction to it are roughly the same in humans and in rodents, which is why it can be said that changes in the structure of the TRPM8 gene can play a very serious role in the development of obesity, which we previously did not suspect, “- write Alfonso Reimundez of the University of Santiago de Compostela (Spain) and his colleagues. According to WHO, since the 1980s, the world has seen a global epidemic of obesity. In the past year, every third inhabitant of the planet (about 1.9 billion people) suffered from extra pounds, about 15 percent had severe forms of pathology. Almost half of the diseases are associated with obesity – such as cardiovascular diseases, diabetes and cancer.
In recent years, scientists are increasingly talking about the relationship between obesity and chronic inflammatory processes. The appearance of extra pounds leads to the development of foci of inflammation, and this, in turn, leads to an even greater weight gain. Moreover, recently biologists found that substances that suppress inflammation – for example, capsaicin (the main component of the burning taste of pepper) – proved to be very effective drugs against excess weight. Scientists found out why chili pepper makes people lose weight
Reymundez and his colleagues found another link between obesity and body temperature. To do this, they observed the behavior of mice in which the TRPM8 gene responsible for the reaction to cold was damaged.
Scientists wondered whether the behavior of rodents will change when this part of DNA is removed. They assumed that mice that lost the ability to feel low and high temperatures would spend more energy in the cold and overheat in the heat.
In fact, the removal of TRPM8 almost did not affect the ability of mice to maintain body temperature – on average, it differed from the norm by only 0.7 degrees and this did not threaten rodents.
On the other hand, gene damage strangely affected the appetite of mice and how their bodies used fat stores when the temperature was lowered. With the onset of cold weather, rodents developed unusual insomnia, which they constantly tried to seize, which led to rapid weight gain and the development of obesity. Scientists have uncovered another positive property of spicy food
As it turned out, the body of mice used for heating not fat reserves, but in fact only those nutrients that got into the blood after the next hike to the feeder.
Interestingly, this obesity did not develop immediately, but only at about the 24th week of rodent life (in humans this corresponds to late adolescence). According to researchers, the disease can similarly develop in people with similar mutations in TRPM8.

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