Scientists in the United States have found that long-term vitamin D3 supplementation is not able to prevent depression, the Journal of the American Medical Association (JAMA Network Open) reported.
In an experiment that lasted more than five years with a total of 18,353 men and women over 50 years old, half of the patients received vitamin D3 and omega-3, and the rest took placebo. At the same time, 16,700 participants had no history of depression, and 1679 people were at risk of relapse, but they did not receive treatment for depression for two years before the start of the study.
Low blood levels of the active metabolite of vitamin D3, 25-hydroxycholecalciferol, have generally been associated with a higher risk of depression in older people, but no one has conducted long-term, large-scale studies on this, experts say.
There were no significant differences between treatment groups in terms of changes in mood indicators over time, the scientists noted, commenting on the results of the experiment.
Moreover, they said that the groups did not differ in the risk of depression: 609 depression or significant symptoms of depression were recorded in the “vitamin D group” and 625 in the “placebo group”.
Among adults aged 50 and over without clinically significant depressive symptoms at baseline, vitamin D3 treatment versus placebo showed no statistically significant difference in the incidence and relapse of depression or clinically significant depressive symptoms or changes in mood scores over a median follow-up of more than five years. , the researchers stated. This led them to conclude that the use of vitamin D3 in adults does not help prevent depression.