Health The life cycle of the 500% worm expands in...

The life cycle of the 500% worm expands in a surprising discovery


  • The experiment was carried out on C. elegans, a nematode species that is often used to research aging.
  • People changed the same cellular pathways, suggesting that the results could help to provide anti-aging therapies to people.
  • The new study focuses on the role of mitochondria in the aging process.

A new study shows that the conversion of two cellular corridors in a life-cycle wheat species can extend by 500 per cent. The discovery could help scientists to develop anti-aging therapies for people, assuming that people have the same cellular pathways in the research.

Scientists have spent decades trying to resolve the mystery of aging by experimenting with known small nematode species. C. elegans. These microscopic worms are suitable for aging research because they only last two or three weeks, meaning that researchers can quickly distinguish the changes or mutations associated with life cycle. In 1993, a famous paper showed that C. elegans who had a single gene mutation lived twice as long as he had no birds. This discovery helped a new era of aging research.

Bob Goldstein

The new study, published in Cell reports, it shows that the insulin trails (IIS) and TOR trails have a lifespan of approximately 500 per cent. This surprised the researchers. After all, previous research on the ISS and TOR routes shows that 100 per cent and 30 percent increase in the respective lifespan due to them changing (through a process called gene knockdown). So they thought that a change of life would make a 130 per cent lifespan. But the effect was greater than her sum.

"The synergist extension is really wild," said Jarod A. Rollins, Ph.D., the author of Jianfeng Lan, Ph.D., from Nanjing University, "The effect is two plus two, is equal to one. Our results show that there is nothing in the vacuum, to develop the most effective anti-aging treatments we need to look at longevity networks rather than individual paths. "

The findings suggest that anti-aging therapies may involve treatment in the future, such as how sometimes combined treatment for cancer and HIV is used.

K. D. Schroeder

The longevity network

To date specific gene scientists have failed to specify why some people live mostly free of disease in old age. Why? In addition to environmental factors affecting aging and health, the answer may be that aging is primarily regulated not by individual genes, but by a "lifetime network", t so-called systems, which include non-body systems. For many years, scientists have been trying to verify the aging process by mapping possible connections within the longevity network. The new study suggests that scientists are beginning to understand how this complex network operates.

The new study focuses specifically on the role that mitochondria, which generate chemical energy in cells, can play in the longevity network. Recent research suggests that mitochondria may play an important role in the aging process, as described in the 2017 overview published in the journal. Genes:

"Among the various factors that contribute to human aging, the mitochondrial dysfunction has emerged as one of the main characteristics of an aging process and is linked to the development of many age-related pathologies, including metabolic syndrome." , neurodegenerative disorders, cardiovascular diseases and cancer. "

It is unclear what impact people may have on the ISS paths and TOR for people. However, a growing research body suggests that promoting a mitochondrial health life can be a reliable way of increasing lifecycle. It is interesting to note that a recent adult study found that taking C. elegans on an intermittent diet helped maintain the round worms mitochondria in a “young” state, similar to longevity.

"Low-energy conditions such as dietary restriction and intermittent fasting have shown that healthy aging conditions are being promoted. This is a crucial step in understanding this in order to be able to benefit in practice. "said Heather Weir, the author of the study, said Harvard News. "Our results provide new ways of searching therapeutic strategies that will reduce the likelihood of developing age-related diseases as we grow older."

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