Tottenham has taken a lone point from their three games and is in Group B in third place before today's game.
Pochettino understands the pressure under which his side stands but demands no less than all three points when the pages meet in Wembley.
"If we want to be in the next phase of the Champions League, we have to win first," said Pochettino.
"We need the three points.
"If we want to be in the next phase of the Champions League, we have to win first."
Mauricio Pochettino – Tottenham boss
"It's going to be a tough game because the Champions League is always tough."
The Spurs have made a good start to their Premier League season this season with eight wins from eleven games. However, they had difficulty reproducing this form for their European relations.
The late goals against Inter Milan and PSV have increased the chances of an early exit from the Champions League.
However, Pochettino are confident that the Carabao Cup's 3-1 victory over rivals West Ham and their 3-1 victory over Wolves in the Premier League put their players in the right mood to move closer to this crucial game.
"After two important wins away we will be ready for the competition again," said Pochettino.
"The team is aware of that and we'll be ready to do our jobs.
"I am satisfied with the team's performance and commitment right from the start.
"I have no doubt that we will compete and perform as expected."
The encounter in Eindhoven ended in a 2-2 draw.
Spurs were 2-1 when their goalkeeper Hugo Lloris was sent off in the 79th minute.
In the 87th minute, the PSV came to a late equalizer by Luuk de Jong. Three points were torn away by Tottenham.
"It was a tough game at PSV," said Pochettino.
"We have earned more. We played better and deserved to win.
"Again they will be fresh. They have rested players. We played three tough matches in three days, now we play the fourth, but we are confident that we can beat them. "
The PSV is the highest score of the Eredivisie after winning all eleven games.
The Dutch side only gained 29 percent of possession in the previous game against Spurs, but PSV boss Mark Van Bommel believes in the players at his disposal.
"We could play [on the counter]but we have several weapons in our team, "he said.
"We want to dominate the game, but we also need to be realistic. Sometimes you will be forced to defend hard, but I know that we are capable of doing so.
"It's not going to be an easy game, it's a must for the Spurs, but if we want to do something, we also have to win.
"Both teams will want to win, so we enjoy it."