Woman immune to Alzheimer's disease – doctors see opportunity for completely new therapies

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Alzheimer's is the forgetting: those affected are mentally reduced, until they do not recognize even more relatives. But researchers now found perhaps the first immune woman.

A 70-year-old has no Alzheimer's: Fortunately, not an isolated case. But the case of a Columbian woman is something very special: her extensive family has been developing Alzheimer's for generations between the ages of 40 and 50 – the most common dementia disease worldwide. The widely branched extended family with around 6,000 relatives is therefore a very interesting research object for physicians.

Resistant to Alzheimer's: Woman gives up puzzles

For generations, a family clan from the Medellin region in Colombia has been struggling with a dreaded disease: Alzheimer's disease. This form of dementia often begins insidiously, those affected increasingly forget things, But it does not stop there, the mental degradation progresses in the course, more and more acquired in the course of life skills are lost, long-term and short-term memory dwindle until dementia patients in the final stage can remember anything and no longer recognize even close relatives ,

Feverish scientists are researching how dementia can be stopped. If the disease has just broken out, the course can be delayed by medication, but a cure is still not possible. However, the case of a Colombian woman is currently bringing movement into the field of researchThus, at the age of more than 70, she is still spared the illness that has befallen her entire family for decades. The woman encountered a research team led by Joseph Arbodela-Velasquez at Harvard Medical School when they examined 1,200 clan members, the Focus reported.

also read: Sleep disorder heralds dementia: Researchers find a surprising connection,

Body's own Alzheimer's protection can open door for new therapies

The scientists found mutant PSEN1 in all family members who are causing the onset of Alzheimer's disease. Although the woman with immunity presented the same gene change, she did not become ill. Responsible for the resistance, the researchers make another gene mutation: The so-called APOE3 variant, also Christchurch mutation.

More about the topic in the video

Although more studies are needed to understand how the body's own dementia protection works exactly. But even now, the discovery of the Alzheimer's protective gene mutation is a milestone in dementia research, which could be the basis for brand new Alzheimer's therapies,

To the study

more on the subjectWith these simple rules, you can reduce your Alzheimer's risk enormously.


Celebrities who lost their memory

Nightmare Alzheimer: The former football player of FC Bayern Munich, Gerd Müller suffers from Alzheimer's disease. A few weeks before his 70th birthday on 3 November, the German football champions and the family of the 1974 World Champion ask for understanding that there will be no public appearances on the occasion of the anniversary. © dpa
Karheinz Böhm
The great actor Karheinz Böhm died on 29 May 2014 at the age of 86 years. It was not until February 2013 that Böhm's Alzheimer's disease became known. His son Michael no longer wanted to keep silent about his father's state of health. Karlheinz Böhm became a star on the side of Romy Schneider in Sissi. Böhm has been working for hungry people in the Sahel since 1981 (archive photo from 2.05.2011). © dpa
Former actor Karlheinz Böhm, who has been running Ethiopia's "People for People" aid for 28 years, and wife Almazs, visit the "Sheikh Abdi Erosion Trench" reforestation project in Ethiopia (photo taken in 2006).
Former actor Karlheinz Böhm has headed Ethiopia's "People for People" since 1981. The photograph from 2006 shows how Böhm and his wife Almazs visit the reforestation project "Sheikh Abdi Erosion Trench" in Ethiopia. © dpa
Rudi Assauer
Rudi Assauer and the terrible diagnosis Alzheimer shook all Germany. His honesty is affecting. © dpa
Schalke manager Rudi Assauer
In a TV appearance at the beginning of 2012, football manager Rudi Assauer speaks openly about his suffering for the first time. And the celebrity is not alone with his heavy fate. © dpa
Ronald Reagan
Former US President Ronald Reagan (1911-2004) did not recognize his wife Nancy one day – after more than 40 years of marriage. © dpa
Ronald Reagan Alzheimer
"I now start the journey that leads me to the sunset of my life …" – In 1994, the former president confessed in a letter as an Alzheimer's patient. This created for the first time a public awareness of the disease. © dpa
Gunter Sachs suicide
He made a name for himself in Europe as a photographer, art collector and playboy: Gunter Sachs. But for fear of Alzheimer's committed at the age of 78 years suicide (7.05.2011). © dpa
Margret Thatcher
Former British Prime Minister Margaret Thatcher is considered adamant and earned her the nickname "The Iron Lady". © dpa
Peter Falk
US actor Peter Falk as Inspector "Columbo" in his typical outfit, the trench coat – and with a cigar in his hand needed full-time care at the end. He suffers from dementia and Alzheimer's disease until the summer of 2011. © dpa
Annie Girardot
The French actress Annie Girardot died at the age of 79 years (28.02.2011) of Alzheimer's. © dpa
Charlton Heston
Alzheimer's sufferer Charlton Heston died at the age of 84. The US actor became known for the movie epic "The Ten Commandments" Moses. For his Judah in "Ben Hur" in 1959 he got the Oscar for Best Actor. © dpa
Bubi Scholz
Again and again Bubi Scholz struggled back to life despite several strokes. The former boxing legend also suffered from Alzheimer's and died at the age of 70 years in Berlin (21.08.2000). © dpa
Country star Glen Campbell, despite his diagnosis of Alzheimer, wanted to go on tour for the last time in autumn 2011 and say goodbye to his fans with several live performances. © dpa
The actor Fred Delmare was one of the best-known GDR actors. Last Delmare was in the ARD series "In all friendship" as Grandpa Friedrich in front of the camera. In 2005, he retired from professional life because of his Alzheimer's disease, where the Mime died in 2009. © dpa
Helmut Zacharias
The violin virtuoso Helmut Zacharias composed 400 pieces, arranged 1,400 titles and sold 13 million records. Most recently, he disappeared from the public eye. The musician suffered from Alzheimer's disease and lived until his death at the age of 82 years (28.02.2002) in a sanatorium near his place of residence Ascona in Switzerland. © dpa
Roberto Blanco
Roberto Blanco and Sodom are rocking together for a spot by the German Alzheimer Society e.V. The singer draws attention to the disease with humor. © obs
A bust of the brain researcher Alois Alzheimer
A bust of the brain researcher Alois Alzheimer: When the psychiatrist first lectured on 3 November 1906 in Tübingen "About a strange serious disease process of the cerebral cortex", colleagues evaluated his discovery as a curiosity. 100 years later, Alzheimer's name is one of the best-known in the world, of the brain disease named after him to be affected in Germany alone 700,000 to one million people. © dpa


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