Alice Whittemore: Cancer Risk Modeler Dies at 89

The field of epidemiology and biostatistics has lost a towering figure with the passing of Alice Whittemore, a Stanford University professor emerita whose groundbreaking work on cancer research and statistical methodology spanned decades. More than just a brilliant scientist, Whittemore’s life exemplified a relentless pursuit of knowledge, a commitment to inclusivity, and a dedication to mentorship that shaped generations of researchers. Her death, at 94, marks not only the end of a remarkable career but also a moment for reflection on the evolving landscape of public health and the importance of rigorous, ethical research.

Whittemore’s career coincided with a period of significant advancement in epidemiological research. As cancer rates rose in the latter half of the 20th century, the need for sophisticated statistical tools to understand risk factors and evaluate interventions became paramount. Whittemore rose to this challenge, developing innovative methods for analyzing data from large-scale studies and clinical trials. Her work wasn’t confined to theoretical advancements; she actively applied her expertise to real-world problems, leading studies on breast cancer, ovarian cancer, and HIV/AIDS. She was a leader in the development of the Stanford-UCSF Cancer Registry, a resource that continues to provide invaluable data for cancer research.

Beyond her scientific achievements, Whittemore was known for her adventurous spirit and unwavering principles. Her annual hiking trips with her husband, Joseph Keller, a renowned mathematician, exemplify a commitment to lifelong learning and physical well-being. Her willingness to walk miles through a city plunged into darkness after Hurricane Sandy, simply to continue her work, speaks to her dedication. Perhaps most powerfully, her public advocacy for LGBTQ+ rights – including refusing to participate in events in hostile environments and openly supporting her daughter – demonstrates a rare courage and a commitment to social justice that extended far beyond the laboratory. This commitment is particularly noteworthy given the historical challenges faced by the LGBTQ+ community and the often-conservative nature of academic institutions.

The Forward Look: Whittemore’s passing comes at a critical juncture for public health. The COVID-19 pandemic underscored the vital role of epidemiology and biostatistics in responding to global health crises. However, it also exposed vulnerabilities in data collection, analysis, and communication. The upcoming symposium in Whittemore’s honor, featuring a keynote from Dr. Mary Beth Terry, signals a renewed focus on methodological rigor and collaborative research. We can expect to see increased emphasis on the principles Whittemore championed – transparency, inclusivity, and a commitment to translating research findings into actionable public health policies. Furthermore, her legacy will likely inspire a new generation of scientists to not only pursue scientific excellence but also to advocate for social justice and equity within the field and beyond. The demand for skilled epidemiologists and biostatisticians will only continue to grow, and Whittemore’s example will serve as a guiding light for those entering the field.

She is survived by her daughters, stepchildren, grandchildren, and sister. A memorial service will be held this summer in Woods Hole, Massachusetts.