Genomics-Guided Off-Label Treatment: Prospective Evaluation

The “Wild West” era of off-label cancer treatment—where clinicians prescribe non-approved drugs based on scientific intuition and hope—is facing a necessary reckoning. For years, patients with exhausted treatment options have navigated a precarious landscape of high-cost, high-toxicity therapies with little to no systematic oversight. However, the long-term results of the Drug Rediscovery Protocol (DRUP) provide … Read more

p53 Mutant Cancer Drug: New Hope in a Small Pill

Rezatapopt Restores Mutant p53 Function in Early Clinical Trial, Offering Hope for Cancer Treatment In a significant breakthrough for cancer research, a novel small molecule, rezatapopt, has demonstrated the ability to reactivate a mutated form of the p53 tumor suppressor protein. Early results from a Phase 1 clinical trial, published online today, suggest this approach … Read more