Health Cellular stress in cortical organoids impairs the specification of...

Cellular stress in cortical organoids impairs the specification of the molecular subtype


  • one)

    Kadoshima, T. et al. The self-organization of axial polarity, the inside-out layer pattern and the specific progenitor dynamics of the species in the neocortex derived from human ES cells. Proc. Natl Acad. Sci. United States 110, 20284-20289 (2013).

  • two)

    Lancaster, M. A. et al. Brain organoids model the development of the human brain and microcephaly. Nature 501, 373–379 (2013).

  • 3)

    Camp, J. G. et al. Human brain organoids recapitulate the gene expression programs of fetal neocortex development. Proc. Natl Acad. Sci. United States 112, 15672-15677 (2015).

  • 4)

    Pollen, A. A. et al. Establishment of brain organoids as models of specific brain evolution of the human being. Cell 176, 743–756.e717 (2019).

  • 5)

    Velasco, S. et al. Individual brain organoids reproducibly form the cellular diversity of the human cerebral cortex. Nature 570, 523-527 (2019).

  • 6)

    Camp, J. G. et al. Multiline communication regulates the development of human liver outbreaks from pluripotence. Nature 546533-538 (2017).

  • 7)

    Wu, H. et al. Comparative analysis and refinement of the differentiation of renal organoids derived from human PSCs with unicellular transcriptomics. Cell Stem Cell 2. 3, 869–881.e868 (2018).

  • 8)

    Sloan, S. A. et al. Maturation of human astrocytes captured in 3D cerebral cortical spheroids derived from pluripotent stem cells. Neuron 95, 779–790.e776 (2017).

  • 9)

    Amiri, A. et al. Transcriptomic and epigenomic landscape of human cortical development modeled on organoids. Sciences 362, eaat6720 (2018).

  • 10)

    Mansour, A. A. et al. A Live model of functional and vascularized human brain organoids. Nat. Biotechnology. 36, 432–441 (2018).

  • eleven)

    Eiraku, M. et al. Self-organized formation of polarized cortical tissues from ESC and their active manipulation by extrinsic signals. Cell Stem Cell 3, 519-532 (2008).

  • 12)

    Xiang, Y. et al. The fusion of regionally specified hPSC derived organoids models human brain development and interneuronal migration. Cell Stem Cell twenty-one, 383–398.e387 (2017).

  • 13)

    Quadrato, G. et al. Cellular diversity and network dynamics in photosensitive human brain organoids. Nature 545, 48–53 (2017).

  • 14)

    Giandomenico, S. L. et al. Brain organoids in the air-liquid interface generate various nerve tracts with functional output. Nat. Neurosci. 22669-679 (2019).

  • fifteen.

    Marton, R. M. et al. Differentiation and maturation of oligodendrocytes in human three-dimensional neuronal cultures. Nat. Neurosci. 22, 484-491 (2019).

  • sixteen.

    Pașca, A. M. et al. 3D human cell model of hypoxic brain injury of prematurity. Nat. Medicine. 25, 784-791 (2019).

  • 17)

    Lui, J. H., Hansen, D. V. and Kriegstein, A. R. Development and evolution of human neocortex. Cell 146, 18–36 (2011).

  • 18)

    Götz, M. and Huttner, W. B. The cellular biology of neurogenesis. Nat. Rev. Mol. Cell biol. 6 6, 777-788 (2005).

  • 19)

    Nowakowski, T. J. et al. The trajectories of space-time gene expression reveal hierarchies of development of the human cortex. Sciences 358, 1318-1323 (2017).

  • twenty)

    Mayer, C. et al. Diversification of the development of cortical inhibitor interneurons. Nature 555, 457–462 (2018).

  • twenty-one)

    Pollen, A. A. et al. Molecular identity of the human external radial glia during cortical development. Cell 163, 55-67 (2015).

  • 22)

    Nowakowski, T. J., Pollen, A. A., Sandoval-Espinosa, C. and Kriegstein, A. R. The transformation of the radial glia scaffold delimits two stages of the development of the human cerebral cortex. Neuron 91 91, 1219-1227 (2016).

  • 2. 3)

    Vaid, S. et al. A new population of basal radial glial cells dependent on Hopx in the development of mouse neocortex. Developing 145, dev169276 (2018).

  • 24)

    Harrington, A. J. et al. MEF2C regulates synapses and inhibitory and cortical excitatory behaviors relevant to neurodevelopmental disorders. eLife 5 5, e20059 (2016).

  • 25)

    Barbosa, A. C. et al. MEF2C, a transcription factor that facilitates learning and memory through negative regulation of numbers and synapse function. Proc. Natl Acad. Sci. United States 105, 9391-9396 (2008).

  • 26)

    Langfelder, P. and Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9 9559 (2008).

  • 27)

    Tasic, B. et al. Types of shared and distinct transcriptomic cells in neocortical areas. Nature 563, 72-78 (2018).

  • 28)

    Saunders, A. et al. Molecular diversity and specializations between adult mouse brain cells. Cell 174, 1015-1030.e1016 (2018).

  • 29)

    Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 999–1014.e1022 (2018).

  • 30)

    Cadwell, C. R., Bhaduri, A., Mostajo-Radji, M. A., Keefe, M. G. and Nowakowski, T. J. Development and arealization of the cerebral cortex. Neuron 103, 980–1004 (2019).

  • 31)

    Simi, A. and Studer, M. Developmental genetic programs and activity-dependent mechanisms instruct the mapping of the neocortical area. Curr. Opin. Neurobiol. 53, 96-102 (2018).

  • 32)

    Yoshida, A. and Tani, K. Phosphoglycerate kinase abnormalities: functional, structural and genomic aspects. Biomed Biochim Minutes 42, S263-S267 (1983).

  • 33)

    Izumi, K. et al. ARCN1 Mutations cause a recognizable craniofacial syndrome due to transport defects mediated by COPI. A.M. J. Hum. Genet. 99, 451–459 (2016).

  • 3. 4)

    Gee, H. Y., Noh, S. H., Tang, B. L., Kim, K. H. and Lee, M. G. Rescue of ΔF508-CFTR traffic through an unconventional secretion pathway dependent on GRASP. Cell 146, 746–760 (2011).

  • 35)

    Kim, J. et al. The monomerization and ER relocation of GRASP is a requirement for unconventional secretion of CFTR. Traffic 17, 733-753 (2016).

  • 36)

    Laguesse, S. et al. A deployed dynamic protein response contributes to the control of cortical neurogenesis. Dev Cell 35553-567 (2015).

  • 37)

    Tseng, K. Y. et al. MANF is essential for the extension of neurites and neuronal migration in the developing cortex. eNeuro 4 4, JANUARY. 0214-17.2017 (2017).

  • 38)

    Shekhar, K. et al. Integral classification of bipolar retinal neurons by unicellular transcriptomics. Cell 166, 1308-1323.e1330 (2016).

  • 39)

    Peng, Y. R. et al. Molecular classification and comparative taxonomy of peripheral and foveal cells in the primate retina. Cell 176, 1222-1237.e1222 (2019).

  • 40)

    Butler, A., Hoffman, P., Smibert, P., Papalexi, E. and Satija, R. Integrating unicellular transcriptomic data through different conditions, technologies and species. Nat. Biotechnology. 36, 411-420 (2018).

  • 41)

    Hoffman, G. E. and Schadt, E. E. VariancePartition: interpretation of the variation factors in complex studies of gene expression. BMC Bioinformatics 17483 (2016).

  • 42)

    Hodge, R. D. et al. Types of conserved cells with divergent characteristics in the human cortex versus that of the mouse. Nature 57361-68 (2019).

  • 43)

    Velmeshev, D. et al. Unicellular genomics identifies specific molecular changes of the cell type in autism. Sciences 364, 685-689 (2019).


    Please enter your comment!
    Please enter your name here

    Latest news

    Corona virus: Chinese returnees thrown at stones in Ukraine

    On Thursday evening, violent clashes between security forces and residents occurred in a village in central Ukraine. The background...

    Matchday 23: Bremen loses, Haaland scores, debacle for Hertha

    Sports Matchday 23 Bremen loses, Haaland scores, Hertha debacle As of: 5:53 p.m....

    Ball: Peña II and Albisu win 18-22 and qualify Olaizola II and Urrutikoetxea

    The victory of Peña II and Albisu by 18-22 over Elezkano II and Rezusta this Saturday at Labrit de...

    Must read

    Corona virus: Chinese returnees thrown at stones in Ukraine

    On Thursday evening, violent clashes between security forces and...

    You might also likeRELATED
    Recommended to you